If you are asking whether api.informationprotection.azure.com is safe, the short answer is yes. This is not a random website — it is a subdomain hosted on Microsoft's Azure cloud. The technical signals back that up: a valid TLS certificate, modern encryption, and hosting on Microsoft's own network infrastructure. There are no blacklists or threat flags against it.
Of course, this is an API endpoint, not a shopping site or a social network. It does not have an about page, contact form, or privacy policy of its own. For a backend service that works with Azure's information protection tools, that's expected. The real question is whether you trust Microsoft as a provider. If you do, there is nothing here to worry about.
For developers considering integration, the bot protection that blocks automated checks is actually a positive sign — it shows security controls are in place. No web archive history might suggest the endpoint is relatively new, but that is not a red flag for a cloud service. In short, api.informationprotection.azure.com is what it appears to be: a legitimate part of the Azure ecosystem.