When you encounter vod-secure.twitch.tv, you are looking at a backend component of the Twitch streaming service. This domain serves as an origin or cache point for video-on-demand files. You will not find a corporate "About" page here because this site is not a destination for consumers. It is a utility for your browser to fetch content while you watch streams.
Most users asking if vod-secure.twitch.tv is a scam are likely concerned because they saw the URL in a network diagnostic log or a browser security warning. Given that this domain has a multi-year history and sits on Amazon’s cloud infrastructure, it is a stable part of the Twitch ecosystem. It is not an independent retailer or a site collecting user information. If your antivirus flags a video site, it is usually because of the content being loaded rather than the delivery infrastructure itself. This domain performs the specific, narrow role of delivering encrypted video streams to your device.